Palmitoylethanolamide or PEA has an internal cause of fatty acid amide in it and is a part of the nuclear factor agonist’s class. This compound is studied in two systems named as vivo and vitro. This is present in these two systems with the help of added compounds or dosed compounds, which are present at some external place.

There are many pieces of evidence that the compound is attached with nuclear receptors and with the help of these receptors, it can exert a no of effects over the biological things and includes some of the chronological inflammation in it with the pain present.

The primary target of this compound is to be peroxisome proliferator-activated receptor alpha (PPAR-a). This compound has some special kind of affinity towards the cannabinoid-like G-coupled receptors, which are named as GPR55 and GPR119.

This is not a strict type of endocannabinoid, which is at the classic level, and the reason behind this is, it does not have an appropriate affinity towards the cannabinoid receptor, which is commonly known as CB1 and CB2.

However, there are many types of research done in this field but the primary one helps us to conclude that it helps in enhancing the anandamide activity along with the encouraging effect.

There are many primary reports and researches that are focused on the PEA that will help us conclude that the levels of PEA can be changed and even the endocannabinoid systems are not balanced whether it is acute inflammation or chronic one.


This compound was discovered in 1957 and the main use of this compound s like as anti-inflammatory and analgesic. In the same year of its discovery, the researchers named this compound as N-(2-hydroxyethyl)-palmitate which is also known as natural inflammatory. Some of the two main sources from where you can isolate this compound are egg yolk and peanut meal.

A study in 1975 clearly mentioned that this compound is highly effective for the joint pains and the analgesic effects of aspirin. Along with it in 1970, the manufacturer Spofa introduced their product named as Impulsion, which is a tablet, manufactured from PEA and it is beneficial for the treatment of respiratory infections.

In 1976, a company named as Admiral introduced their product named as Plamidrol. Moreover in 1990 the relationship between PEA and anandamide. This relationship could be described as the mast cell receptors that are demonstrated between coworkers and Levi-Montalcini.

Palmitoylethanolamide: History and Researches


There are many of the researches that are conducted on animals and in these studies, the researchers become able to demonstrate the efficiency of this compound and along with it, they have also demonstrated the negative impacts that it will cause to the body of the individual.


With the final words, we conclude that here we have discussed Palmitoylethanolamide and along with it we have discussed the history of the medicine and the researches that are conducted to know about this compound more, and the details mentioned by us are quite specific. You can get more information of it, you can view here.